Dive deep into “Lessons in Chemistry” with our comprehensive book club discussion guide. Explore gender equality, science, and society through thought-provoking questions and engaging activities.
Ready to dive deep into Bonnie Garmus’s groundbreaking debut novel? Whether you’re a passionate book club moderator or a first-time reader, this comprehensive guide will help spark meaningful conversations about “Lessons in Chemistry.”
Table of Contents
Introduction: Why “Lessons in Chemistry” Resonates with Modern Readers
When Elizabeth Zott steps into our lives through the pages of “Lessons in Chemistry,” she brings more than just molecular formulas and precise measurements. She carries with her a story that, despite being set in the 1960s, feels startlingly relevant today. As someone who’s led numerous book club discussions, I’ve watched readers’ eyes light up when they recognize their own struggles in Elizabeth’s journey.
Core Themes to Explore
Before we dive into specific questions, let’s establish the fundamental themes that make this novel so compelling:
Gender Equality and Professional Recognition
Elizabeth’s battle for recognition in the male-dominated field of chemistry mirrors contemporary discussions about gender equality in STEM fields. Her experiences, though set decades ago, continue to spark important conversations about workplace discrimination and professional respect.
The Intersection of Science and Society
The novel brilliantly weaves scientific principles into everyday life, showing how chemistry exists not just in laboratories but in cooking, relationships, and personal growth. This unique approach raises questions about how we compartmentalize knowledge and experience.
Resilience and Authenticity
Through Elizabeth’s unwavering commitment to being herself, the novel explores what it means to stay true to one’s principles in the face of societal pressure.

Essential Discussion Questions
Opening Questions: Setting the Stage
- How does your personal experience with science influence your reading of Elizabeth’s story?
- What was your initial reaction to Elizabeth’s approach to life and her dedication to scientific precision?
Character Deep Dive
- Elizabeth Zott’s Evolution
- How does Elizabeth’s background shape her approach to both chemistry and cooking?
- What role does her precision play in both her professional and personal life?
- In what ways does she challenge the traditional narrative of what a “woman’s role” should be?
- Calvin Evans as a Catalyst
- How does Calvin’s support of Elizabeth differ from other male characters?
- What does their relationship reveal about gender dynamics in the scientific community?
- Why do you think Elizabeth initially resists Calvin’s marriage proposal?
- Six Thirty’s Unique Perspective
- What does the inclusion of Six-Thirty’s viewpoint add to the narrative?
- How does his character development parallel Elizabeth’s journey?
- Why might Garmus have chosen to give such depth to a canine character?
Thematic Exploration
- Science and Society
- How does the novel use chemistry as a metaphor for human relationships?
- What parallels can you draw between Elizabeth’s approach to chemistry and her approach to life?
- How does “Supper at Six” challenge traditional cooking shows of the era?
- Gender Dynamics and Power Structures
- What specific instances of sexism in the novel felt most familiar or relevant today?
- How does Elizabeth’s response to discrimination evolve throughout the story?
- What role does education play in challenging gender norms?
Contemporary Relevance
- Then and Now
- Which aspects of Elizabeth’s struggles still resonate in today’s professional world?
- How might Elizabeth’s story be different if it were set in 2025?
- What progress has been made since the 1960s, and what still needs to change?
Activity Suggestions for Book Clubs
The Chemistry of Cooking
Organize a cooking session where members prepare one of Elizabeth’s recipes while discussing the scientific principles behind cooking. This hands-on activity can lead to fascinating discussions about how science permeates our daily lives.
Historical Context Timeline
Create a timeline of women in science, placing Elizabeth’s fictional story alongside real historical achievements. This can spark discussions about representation and recognition in scientific fields.
Character Perspective Exercise
Have members write a short scene from Six-Thirty’s perspective, followed by a discussion about why Garmus chose to include this unique viewpoint in the novel.
Must-Read Books If You Loved “Lessons in Chemistry” 📚
Found yourself missing Elizabeth Zott’s wit and wisdom? These captivating reads will fill that lab-coat-shaped hole in your heart.
For the Science Enthusiast
📚 “The Immortal Life of Henrietta Lacks” – Where science meets social justice, this true story will change how you see medical ethics forever.
For the Romance Lover
📚 “The Rosie Project” – When a genetics professor designs a scientific method to find love, chaos (and charm) ensues.
For the History Buff
📚 “Hidden Figures” – The groundbreaking true story of the brilliant Black women mathematicians who helped win the space race.
Pro Tip: These books pair perfectly with a cup of coffee and a notebook for all the quotes you’ll want to remember ☕️

📚 “Lessons in Chemistry” by Bonnie Garmus
📖 Genre: Historical Fiction/Literary Fiction/Women’s Fiction
💬 Why Everyone Is Reading It:
- “This book absolutely WRECKED me! Elizabeth Zott is the feminist icon we need!”
- “The way this combines science and feminism is chef’s kiss.“
- “Six-Thirty (the dog) deserves his own book, I’m just saying 🐕”
- “Me, sobbing into my pillow at 3 AM because of Calvin Evans 😭”
- “The cooking show scenes are giving Julia Child meets Ms. Frizzle energy, and I’m HERE for i.t”
😭 Why BookTok is obsessed:
- A brilliant female scientist in the 1960s who refuses to back down? ICONIC
- The chemistry puns and science references are actually genius
- There’s a super-smart dog who understands thousands of words
- The romance subplot will break your heart in the best way
- It tackles serious feminist issues while still being funny and warm
- The cooking show “Supper at Six” sections are pure gold
- Everyone’s mom/aunt/book club is reading it, but it actually lives up to the hype
- The perfect mix of humor and emotional depth
- The audiobook narrator NAILS Elizabeth’s voice
Want to make BookTok sob? Just mention >!Calvin’s death!< or Six-Thirty’s observations about humans. Gets them every time! 🥺📚
🔗 Where to Buy: [amazon.com]
Recommended Reading Pairings
For book clubs looking to expand their reading list with similar themes:

📚 “The Immortal Life of Henrietta Lacks by Rebecca Skloot
Explores ethics in science and women’s contributions to scientific advancement
📖 Genre: Narrative Non-Fiction/Science/Biography
💬 Why Everyone Is Reading It:
- “Can’t believe this is a true story. I’m shook 😱”
- “The way science and social justice intersect in this book is EVERYTHING.”
- “Started for a school assignment, ended up crying at 2 AM.”
- “If you liked Lessons in Chemistry, this will blow your mind.”
- “The ethics discussions in my comments are getting WILD.”
😭 Why BookTok is obsessed:
- It’s a true story that reads like fiction
- Exposes racial injustice in medical science
- Shows how one woman’s cells changed medicine forever
- The perfect mix of science and human story
- Makes complicated science accessible
- The family’s journey to uncover the truth is heartbreaking
- Great for readers who want to dive deeper into science ethics
- It will make you question everything you know about medical consent
🔗 Where to Buy: [amazon.com]

📚 “The Rosie Project” by Graeme Simsion
Offers another perspective on love and science
📖 Genre: Contemporary Fiction/Romance/Literary Fiction
💬 Why Everyone Is Reading It:
- “Don Tillman is literally me trying to find love 😂”
- “The autism rep we didn’t know we needed!”
- “Scientists can be romantic leads, and I’m here for it.”
- “This book made me snort-laugh in public.”
- “If you love The Big Bang Theory but make it actually goo.d”
😭 Why BookTok is obsessed:
- The protagonist is giving the neurodivergent king energy
- The perfect blend of romance and science
- Actually funny without being cruel
- The quest for love through the scientific method is a chef’s kiss
- It’s a wholesome romance that doesn’t feel cheesy
- Shows that everyone deserves love
- The character growth is incredible
- It will make you laugh AND cry
🔗 Where to Buy: [amazon.com]

📚 “Hidden Figures” by Margot Lee Shetterly
Examines the real-life struggles of women in science during a similar era
📖 Genre: Historical Non-Fiction/Science/Biography
💬 Why Everyone Is Reading It:
- “The movie was great, but the book is NEXT LEVEL.”
- “These women were literal geniuses, and no one knew 😤”
- “My STEM major self is feeling so inspired rn”
- “The way they fought racism AND gravity? Queens 👑”
- “This should be required reading in school,s period.”
😭 Why BookTok is obsessed:
- Tells the untold story of Black women in NASA
- Shows real-life examples of breaking glass ceilings
- The math and physics details are actually fascinating
- Proves that representation in STEM has always mattered
- These women literally helped put people in space
- The perfect mix of science and civil rights history
- Shows how far we’ve come (and how far we still need to go)
- Will make you angry but also inspired
🔗 Where to Buy: [amazon.com]
Conclusion: The Lasting Impact of “Lessons in Chemistry”
“Lessons in Chemistry” does more than tell a story—it challenges us to examine our own biases, consider the role of science in our daily lives, and question the structures that still limit human potential. As you discuss this novel with your book club, remember that, like any good chemical reaction, the most interesting insights often come from unexpected combinations of perspectives and experiences.